Table S1.

Hematological values of beagle dogs in 4-week toxicity study of Fe₃O₄@Au composite MNPs

Group/parameter (units)	WBC (×109/L)	RBC (×1012/L)	Hb (mg/mL)	PLT (×109/L)	Neu (×109/L)	Lymp (×109/L)
Before administration
Control	11.69 ± 1.80	7.17 ± 0.36	160.17 ± 14.73	298.83 ± 69.34	2.15 ± 1.47	9.00 ± 1.50
Experimental	9.65 ± 2.23	7.23 ± 0.27	168.00 ± 10.24	355.00 ± 103.54	2.35 ± 1.52	7.04 ± 0.83
1 week after administration
Control	11.45 ± 1.87	7.48 ± 0.44	171.00 ± 19.31	274.50 ± 43.08	2.50 ± 1.53	8.67 ± 0.70
Experimental	11.61 ± 3.56	7.18 ± 0.32	167.67 ± 13.85	307.17 ± 88.05	2.38 ± 0.82	9.31 ± 3.11
2 weeks after administration
Control	13.46 ± 2.04	7.52 ± 0.65	170.00 ± 21.82	240.67 ± 27.96	2.76 ± 2.03	10.06 ± 3.07
Experimental	12.01 ± 2.50	7.52 ± 0.45	176.67 ± 12.50	340.83 ± 113.71	2.78 ± 1.66	8.66 ± 2.28
3 weeks after administration
Control	10.88 ± 3.03	7.09 ± 0.86	161.33 ± 28.24	274.00 ± 53.23	2.61 ± 1.19	7.82 ± 2.14
Experimental	14.20 ± 3.13	7.30 ± 0.43	171.67 ± 11.91	291.83 ± 60.71	2.81 ± 1.48	10.99 ± 3.09
4 weeks after administration
Control	12.76 ± 1.79	7.15 ± 0.38	156.83 ± 19.95	261.67 ± 38.07	3.35 ± 1.55	8.57 ± 0.59
Experimental	11.49 ± 2.04	7.11 ± 0.50	165.17 ± 10.87	322.17 ± 77.87	2.88 ± 1.09	7.95 ± 1.37

Notes: n = 6, mean ± standard deviation. There was no significant difference in hematological values of beagle dogs between the experimental group and the control group at the five time points of before administration and 1, 2, 3, and 4 weeks after administration of Fe₃O₄@Au composite MNPs (P > 0.05).

Abbreviations: MNPs, magnetic nanoparticles; WBC, white blood cells; RBC, red blood cells; Hb, hemoglobin concentration; PLT, platelets; Neu, neutrophils; Lymp, lymphocytes.