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. 2011 Nov 11;6:2865–2872. doi: 10.2147/IJN.S26306

Table 3.

Rat pharmacokinetic parameters following intravenous administration of 50 mg/kg mPEG-ROP conjugates (means ± SD, n = 3)

Parametera ROP10 1.03P20k-R26 0.99P30k-R 0.98P40k-R
AUC0–∞ (g · h/L) 0.170 ± 0.024 3.05 ± 0.45 7.30 ± 0.94 23.7 ± 4.5b
MRT0–∞ (hours) 0.826 ± 0.031 22.4 ± 8.0 54.4 ± 12.7 83.2 ± 2.6c
t1/2 (hours)d 0.724 ± 0.004 35.6 ± 9.0 78.4 ± 12.2 88.3 ± 3.0e
Vss (mL/kg) 314 ± 46 853 ± 217 778 ± 109 276 ± 60
CL (L/h per kg) 0.300 ± 0.044 0.017 ± 0.003 0.007 ± 0.001 0.002 ± 0.000
a

Notes: Calculated by noncompartmental moment analysis assuming first-order elimination;

b

P < 0.01, compared with 0.99P30k-R;

c

P < 0.05, compared with 0.99P30k-R;

d

calculated from the elimination rate constant (λZ) using the formula t1/2 = 0.693/λZ;

e

P > 0.05, compared with 0.99P30k-R.

Abbreviations: AUC, area under the curve; CL, systemic clearance; mPEG, methoxy-polyethylene glycol; MRT, mean residence time; P, mPEG; R, ROP; ROP, radix ophiopogonis polysaccharide; SD, standard deviation; t1/2, half-life; Vss, total volume of distribution.