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. 2011 Nov 11;6:2865–2872. doi: 10.2147/IJN.S26306

Table 4.

Rat pharmacokinetic parameters following subcutaneous administration of 50 mg/kg mPEG-ROP conjugates (means ± SD, n = 3)

Parametera ROP 1.03P20k-R26 0.99P30k-R 0.98P40k-R
AUC0–∞ (g · h/L) 0.160 ± 0.010 2.10 ± 0.46 5.50 ± 0.74 10.4 ± 0.8b
MRT0–∞ (hours) 1.08 ± 0.04 58.4 ± 8.7 89.2 ± 1.3 131 ± 6b
t1/2 (hours)c 0.577 ± 0.082 35.1 ± 15.7 66.8 ± 9.0 89.2 ± 4.4d
ka (×10−2)e 394 2.78 2.87 2.09
Cmax (mg/L) 118 ± 13 43.7 ± 4.5 86.8 ± 17.1 99.4 ± 9.4f
Tmax (hours) 0.444 ± 0.192 18.7 ± 4.6 24.0 ± 0.0 30.0 ± 0.0
F (%) 94.1 68.9 75.4 43.9
CL/F (L/h per kg) 0.328 ± 0.020 0.025 ± 0.005 0.009 ± 0.001 0.005 ± 0.001
a

Notes: Calculated by noncompartmental moment analysis assuming first-order elimination;

b

P < 0.01, compared with 0.99P30k-R;

c

calculated from the elimination rate constant (λZ) using the formula t1/2 = 0.693/λZ;

d

P < 0.05, compared with 0.99P30k-R;

e

estimated as the reciprocal of MAT (MAT = MRTsc – MRTiv);

f

P > 0.05, compared with 0.99P30k-R.

Abbreviations: AUC, area under the curve; CL, systemic clearance; Cmax, maximal concentration; F, absolute bioavailability; ka, absorption rate constant; mPEG, methoxy-polyethylene glycol; MRT, mean residence time; MRTiv, MRT intravenous; MRTsc, MRT subcutaneous; P, mPEG; R, ROP; ROP, radix ophiopogonis polysaccharide; SD, standard deviation; t1/2, half-life; Tmax, time to maximal concentration.