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. 2011 Nov 17;6:2889–2898. doi: 10.2147/IJN.S25162

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© 2011 Gu et al, publisher and licensee Dove Medical Press Ltd.

This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

PMC Copyright notice

Cytotoxicity of the DOX-conjugated SWNTs. (A) Cytotoxicity of SWNT-DOX and SWNT-HBA-DOX against HepG2 cells. (B) Viability of HepG2 cells treated with SWNT-DOX and SWNT-HBA-DOX (DOX concentration: 10 μg/mL) for 2 hours, washed with phosphate buffered saline, then continued incubating in fresh culture media for another 24, 48, and 72 hours. (C) Average intracellular DOX fluorescence intensity (20 cells) after release for 24 hours in fresh medium in SWNT-DOX- and SWNT-HBA-DOX-treated HepG2 cells.

Notes: All values are mean ± standard deviation; *denotes P < 0.05, analysis of variance.

Abbreviations: DOX, doxorubicin; HBA, hydrazinobenzoic acid; SWNT, singlewalled carbon nanotube.