Table 1.

Time-averaged and time-maximum particle concentrations in tumor versus surrounding normal tissue

Case	Time averaged				Time maximum
	Normal	Tumor	T:N	Fold increase	Normal	Tumor	T:N	Fold increase
a. Diffusion only	20.4% ± 3.7%	9.9% ± 4.5%	0.49		28.9% ± 4.3%	15.8% ± 5.2%	0.55
b. Left shift	19.6% ± 3.2%	15.8% ± 3.5%	0.81	1.65	27.4% ± 4.1%	27.4% ± 2.9%	1.00	1.81
c. Shift two directions	19.7% ± 2.8%	18.0% ± 2.6%	0.91	1.86	29.0% ± 3.3%	30.1% ± 2.4%	1.04	1.89

Notes: The time-averaged “normal” and “tumor” values for the three treatment cases were computed by taking the average concentration over time within each tissue region (normal or tumor). Likewise, the time-maximum “normal” and “tumor” values were computed by taking the maximum over time at each location and then spatially averaging that value across the normal and tumor regions, respectively. Time-averaged ratio T:N = tumor average/normal average, and the fold increase = T:N average (left magnet or shift two directions)/T:N average (diffusion only); likewise, the time-maximum ratio T:N = tumor max/normal max, and the fold increase = T:N max (left magnet or shift two directions)/T:N max (diffusion only). The standard deviations are shown next to each percentage to quantify the spatial variance around the timeaveraged or time-maximum region concentrations. T:N values close to unity correspond to effective therapy normalization between tumor and normal tissue; fold increases quantify the benefit of dynamic magnetic shift.