. Author manuscript; available in PMC: 2012 Nov 29.

Published in final edited form as: J Am Coll Cardiol. 2011 Nov 29;58(23):2372–2379. doi: 10.1016/j.jacc.2011.08.035

Table 2.

Association of Fetuin-A with Continuous Measures of Subclinical CVD: The Rancho Bernardo Study

	Fetuin-A Quartiles				Fetuin-A Continuous

Fetuin-A range (g/L)	I < 0.45	II 0.45–0.51	III 0.52–0.58	IV ≥ 0.59	Per SD (0.11 g/L) greater
Coronary Artery Calcification (Ln[CAC + 1])
Number	86	97	95	104	382
Age and sex adjusted; β (95% CI) P-value	1.00 (Ref)	−0.33 (−0.95, 0.30); 0.31	−0.32 (−0.95, 0.31); 0.32	−0.63 (−1.25, −0.02); 0.04	−0.24 (−0.45, −0.02); 0.03
Lifestyle Adjusted; β (95% CI) P-value^*	1.00 (Ref)	−0.32 (−0.95,0.31); 0.32	−0.31 (−0.95, 0.32); 0.33	−0.58 (−1.21, 0.04); 0.07	−0.21 (−0.44, 0.01); 0.06
Fully Adjusted; β (95% CI) P-value^**	1.00 (Ref)	−0.40 (−1.03, 0.22); 0.21	−0.44 (−1.07, 0.20); 0.18	−0.80 (−1.44, −0.16); 0.01	−0.31 (−0.54, −0.08); 0.008
Ankle Brachial Index
Number	280	270	250	245	1045
Age and sex adjusted; β (95% CI) P-value	1.00 (Ref)	0.01 (−0.01, 0.04); 0.36	0.03 (0.01, 0.04); 0.02	0.01 (−0.01, 0.04); 0.34	0.01 (−0.002, 0.02); 0.15
Lifestyle Adjusted; β (95% CI) P-value^*	1.00 (Ref)	0.01 (−0.01, 0.03); 0.46	0.03 (0.002, 0.05); 0.04	0.01 (−0.01, 0.04); 0.39	0.01 (−0.003, 0.02); 0.16
Fully Adjusted; β (95% CI) P-value^**	1.00 (Ref)	0.01 (−0.01, 0.04); 0.44	0.03 (0.002, 0.05); 0.03	0.02 (−0.01, 0.04); 0.16	0.01 (0.000, 0.02); 0.04
Common Carotid Intima Media Thickness (ln[common cIMT])
Number	131	150	148	168	597
Age and sex adjusted; β (95% CI) P-value	1.00 (Ref)	−0.02 (−0.06, 0.02); 0.30	−0.01 (−0.05, 0.04); 0.79	0.03 (−0.01, 0.07); 0.20	0.01 (−0.002, 0.03); 0.10
Lifestyle Adjusted; β (95% CI) P-value^*	1.00 (Ref)	−0.02 (−0.06, 0.02); 0.37	−0.01 (−0.05, 0.04); 0.82	0.03 (−0.01, 0.07); 0.20	0.01 (−0.003, 0.03); 0.11
Fully Adjusted; β (95% CI) P-value^**	1.00 (Ref)	−0.03 (−0.07, 0.02); 0.25	−0.01 (−0.06, 0.03); 0.51	0.01 (−0.03, 0.06); 0.53	0.01 (−0.01, 0.02); 0.36
Internal Carotid Intima Media Thickness (ln[internal cIMT)])
Number	125	149	143	166	583
Age and sex adjusted; β (95% CI) P-value	1.00 (Ref)	−0.004 (−0.11, 0.10); 0.94	0.04 (−0.07, 0.14); 0.47	0.06 (−0.04, 0.17); 0.23	0.02 (−0.02, 0.06); 0.26
Lifestyle Adjusted; β (95% CI) P-value^*	1.00 (Ref)	0.01 (−0.10, 0.11); 0.89	0.04 (−0.06, 0.15); 0.41	0.07 (−0.03, 0.18); 0.19	0.02 (−0.01, 0.06); 0.21
Fully Adjusted; β (95% CI) P-value^**	1.00 (Ref)	−0.004 (−0.11, 0.10); 0.95	0.02 (−0.09, 0.13); 0.71	0.02 (−0.09, 0.12); 0.75	0.001 (−0.04, 0.04); 0.95

Adjusted for age, sex, current smoking, alcohol use, regular physical exercise, and oral estrogen use.

^**

Adjusted for lifestyle model (*) plus diabetes, bmi, total chol., triglycerides, and eGFR.