Table 3.
Association of Fetuin-A with Categorical Definitions of Subclinical Cardiovascular Disease: The Rancho Bernardo Study
| Fetuin-A Quartiles | Fetuin-A Continuous | ||||
|---|---|---|---|---|---|
| Fetuin-A range (g/L) | I ≤ 0.45 |
II 0.45–0.51 |
III 0.52–0.58 |
IV ≥ 0.59 |
Per SD (0.11 g/L) greater |
| CAC severity (0, 1–100, 101–300, >300) | |||||
| N with CAC>0/Total (%) | 69/86 | 76/97 | 66/95 | 75/104 | 286/382 |
| Age and sex adjusted; OR (95% CI) P-value | 1.00 (Ref) | 0.74 (0.43, 1.27); 0.27 | 0.72 (0.42, 1.25); 0.24 | 0.58 (0.34, 0.99); 0.04 | 0.81 (0.67, 0.98); 0.03 |
| Lifestyle Adjusted; OR (95% CI) P-value* | 1.00 (Ref) | 0.71 (0.41, 1.24); 0.23 | 0.71 (0.41, 1.23); 0.22 | 0.56 (0.33, 0.98); 0.04 | 0.81 (0.66, 0.98); 0.03 |
| Fully Adjusted; OR (95% CI) P-value** | 1.00 (Ref) | 0.65 (0.37, 1.14); 0.13 | 0.61 (0.35, 1.08); 0.09 | 0.45 (0.25, 0.79); 0.006 | 0.72 (0.59, 0.89); 0.002 |
| PAD (ABI < 0.90) | |||||
| N with PAD/Total (%) | 40/280 | 36/270 | 25/250 | 28/245 | 129/1045 |
| Age and sex adjusted; OR (95% CI) P-value | 1.00 (Ref) | 0.99 (0.61, 1.62); 0.98 | 0.73 (0.43, 1.23); 0.24 | 0.88 (0.52, 1.48); 0.62 | 0.93 (0.76, 1.12); 0.43 |
| Lifestyle Adjusted; OR (95% CI) P-value* | 1.00 (Ref) | 1.02 (0.62, 1.67); 0.94 | 0.72 (0.42, 1.24); 0.24 | 0.87 (0.51, 1.48); 0.60 | 0.92 (0.75, 1.12); 0.40 |
| Fully Adjusted; OR (95% CI) P-value** | 1.00 (Ref) | 1.05 (0.63, 1.73); 0.86 | 0.73 (0.42, 1.26); 0.26 | 0.78 (0.45, 1.37); 0.39 | 0.88 (0.71, 1.08); 0.22 |
| Common cIMT (> 75th Percentile vs. Lower) | |||||
| N with high common cIMT/Total (%) | 36/131 | 29/150 | 32/148 | 52/168 | 149/597 |
| Age and sex adjusted; OR (95% CI) P-value | 1.00 (Ref) | 0.73 (0.40, 1.32); 0.30 | 0.77 (0.43, 1.38); 0.38 | 1.79 (1.03, 3.11); 0.04 | 1.27 (1.03, 1.57); 0.02 |
| Lifestyle Adjusted; OR (95% CI) P-value* | 1.00 (Ref) | 0.72 (0.39, 1.31); 0.28 | 0.76 (0.42, 1.37); 0.35 | 1.76 (1.00, 3.10); 0.05 | 1.27 (1.03, 1.58); 0.03 |
| Fully Adjusted; OR (95% CI) P-value** | 1.00 (Ref) | 0.65 (0.35, 1.20); 0.17 | 0.65 (0.35, 1.20); 0.17 | 1.50 (0.84, 2.69); 0.17 | 1.20 (0.96, 1.50); 0.11 |
| Internal cIMT (> 75th Percentile vs. Lower) | |||||
| N with high internal cIMT/Total (%) | 27/125 | 33/149 | 38/143 | 47/166 | 145/583 |
| Age and sex adjusted; OR (95% CI) P-value | 1.00 (Ref) | 1.06 (0.60, 1.90); 0.83 | 1.32 (0.75, 2.34); 0.34 | 1.66 (0.95, 2.88); 0.07 | 1.19 (0.98, 1.46); 0.08 |
| Lifestyle Adjusted; OR (95% CI) P-value* | 1.00 (Ref) | 1.09 (0.60, 1.95); 0.78 | 1.34 (0.75, 2.39); 0.32 | 1.66 (0.94, 2.92); 0.08 | 1.20 (0.97, 1.47); 0.09 |
| Fully Adjusted; OR (95% CI) P-value** | 1.00 (Ref) | 1.05 (0.57, 1.93); 0.87 | 1.26 (0.69, 2.30); 0.45 | 1.35 (0.74, 2.47); 0.32 | 1.10 (0.88, 1.36); 0.40 |
*
Adjusted for age, sex, current smoking, alcohol use, regular physical exercise, and oral estrogen use.
**
Adjusted for lifestyle model (*) plus diabetes, bmi, total chol., triglycerides, and eGFR.