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. 2011 Oct 5;31(40):14413–14423. doi: 10.1523/JNEUROSCI.3135-11.2011

Figure 8.

Figure 8.

The cone pathway is also affected by ApoER2 and VLDLR deficiency. A, The amplitude of synaptic transmission through the cone pathway was enhanced in VLDLR KO (MA, p < 0.05). In addition, there were delayed response intervals in VLDLR KO mice (MA, p < 0.05) and a faster interval in ApoER2-EIG mice (YA, p < 0.05). B, The 30 Hz CFR amplitude was impaired in ApoER2 KOs (MA, p < 0.01) and VLDLR KOs (MA, p < 0.01), with an age-dependent reduction seen in both ApoER2 and VLDLR KOs (p < 0.01). No significant strain- or age-dependent differences were detected in the response interval of 30 Hz cone flicker responses (p > 0.05). Error bars indicate SEM. *p < 0.05 (significance when compared to within age-group wild-type controls indicated by two-tailed Student's t test); #p < 0.05 (significance when MA compared to same YA group indicated by two-tailed Student's t test).