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Loss of ApoER2 and VLDLR alters fundus morphology at middle age. A, VLDLR KO mice displayed reported widespread, patchy, dark deposits across the fundus, while ApoER2 KO mice were similar to wild-type mice. B, VLDLR and ApoER2 KO mice both had capillary leakage indicated by FA; however, the leakage was much more severe in VLDLR KO. Thinning of the capillary layer was also evident in VLDLR KOs.
