Skip to main content
. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Trends Immunol. 2011 Sep 28;32(12):603–611. doi: 10.1016/j.it.2011.08.003

Figure 2. IL-17+ cells and psoriasis.

Figure 2

(a) CCL20 mediates the recruitment of Th17 and Tc17 into a psoriatic lesion. (b) IL-1 and IL-23 derived from psoriatic myeloid APCs and possibly BCDA− dendritic cells (DCs) expand both local Th17 and Tc17 populations. Psoriatic Th17 and Tc17 cells express IL-17 and IFNγ. (c) Psoriatic Th17 and Tc17 cells express polyfunctional cytokines including IL-17 and IFNγ. (d) Th17 and Th1 derived cells induce keratinocytes to secrete β-defensin 2 and CCL20, which further increase the recruitment of Th17 and Tc17 cells into the lesion and promote keratinocyte proliferation. (e) IFNγ derived from Th1 and Th17 cells stimulates myeloid APCs to produce higher amounts of the Th17-polarizing cytokines IL-1 and IL-23, and further enhances Th17 and Tc17 development. The interactions between Th1 and IL-17+ cells positively impact IL-17+ cell development, recruitment and function in the psoriatic environment. The information summarizes established concepts in literature.