Figure 8.
Facilitation of transmitter release is still observed in the absence of SK2 channel activation. Responses in OHCs recorded at a Vh of −82 mV with an intracellular solution containing 10 mm of the fast calcium chelator, BAPTA, to minimize the activation of SK2 channels. In A, representative traces of 10 individual responses to 10 shock trains (gray traces) applied at 50 Hz. The black trace is the average response of 50 repetitions. An average response to a single shock (1 Hz stimulation frequency) is shown in the inset. The probability of release (P), the eIPSCs average amplitude (A), and the average response (S) were computed for every pulse during the 10 shock trains. In B, the normalized mean values for these parameters are plotted versus the pulse number (n = 7 OHCs).