Table I.
Type 1 IFN response gene profiling of FL-DCs after HTLV-1 infection compared with control (noninfected) cells
| Symbol | Description | Fold Change |
|---|---|---|
| Type 1 IFN response genes | ||
| Ligands and their receptors | ||
| Ifna2 | IFN-α2 | 12.4 |
| Ifna4 | IFN-α4 | 18.3 |
| Ifnar1 | IFN (α and β) receptor 1 | 10.0 |
| Ifnar2 | IFN (α and β) receptor 2 | 31.8 |
| Ifnb1 | IFN-β1, fibroblast | 19.3 |
| Signaling molecules | ||
| stat1 | Signal transducer and activator of transcription 1 | 8.1 |
| stat2 | Signal transducer and activator of transcription 2 | 11.0 |
| IFN-responsive genes | ||
| Adar | Adenosine deaminase, RNA-specific | 7.7 |
| Anxa11 | Annexin A11 | 8.6 |
| Casp1 | Caspase 1 | 9.8 |
| Cxcl10 | Chemokine (CXC motif) ligand 10 | 15.5 |
| Eif2ak2 | Eukaryotic translation initiation factor 2α kinase 2 | 9.9 |
| Ifi204 | IFN-activated gene 204 | 8.4 |
| Ifit1 | IFN-induced protein with tetratricopeptide repeats 1 | 2.5 |
| Isg15 | ISG15 ubiquitin-like modifier | 12.6 |
| Isg20 | IFN-stimulated protein | 14.6 |
| Mx1 | Myxovirus (influenza virus) resistance 1 | 4.5 |
| MyD88 | Myeloid differentiation primary response gene 88 | 7.3 |
| Nmi | N-myc (and stat) interactor | 2.6 |
| Oas1a | 2′-5′ oligoadenylate synthetase 1A | 13.6 |
| Tap1 | Transporter 1, ATP-binding cassette, subfamily B (MDR/TAP) |
13.4 |
| Tnfsf10 | TNF (ligand) superfamily, member 10 | 26.2 |
| Genes associated with intrinsic IFN resistance | ||
| Signal transduction | ||
| Prkcz | Protein kinase C, ζ | −2.2 |
| Apoptosis | ||
| Dad1 | Defender against cell death 1 | −2.2 |
| Diablo | Diablo homolog (Drosophila) | 9.7 |
| Transcription regulation | ||
| Atf5 | Activating transcription factor 5 | 2.1 |
| Irf2 | IFN regulatory factor 2 | 3.1 |
| Irf3 | IFN regulatory factor 3 | −3.1 |
| Pttg1 | Pituitary tumor-transforming gene 1 | 5.5 |
| Cell growth | ||
| Cd70 | CD70 Ag | 59.3 |
| Cdkn1b | Cyclin-dependent kinase inhibitor 1B | −7.5 |
| Hoxb2 | Homeo box B2 | 2.0 |
| Ifi204 | IFN-activated gene 204 | 8.4 |
| Vegfa | Vascular endothelial growth factor A | 170.8 |
| Others | ||
| Bst2 | Bone marrow stromal cell Ag 2 | −5.2 |
| Cnp | 2′,3′-cyclic nucleotide 3′ phosphodiesterase | −3.5 |
| H2-D1 | Histocompatibility 2, D region locus 1 | −3.8 |
| H2-K1 | Histocompatibility 2, K1, K region | −2.3 |
| H2-M10.1 | Histocompatibility 2, M region locus 10.1 | 3.7 |
| Nrg1 | Neuregulin 1 | −4.2 |
The array was repeated three times to validate the findings.
−, Downregulation.