Table II.
DC functional gene profiling of FL-DCs after HTLV-1 infection compared with control (noninfected) cells
| Symbol | Description | Fold Change |
|---|---|---|
| Cytokines, chemokines, and their receptors | ||
| Ccl2 | Chemokine (CC motif) ligand 2 | −5.2 |
| Ccl5 | Chemokine (CC motif) ligand 5 | 49.0 |
| Ccl7 | Chemokine (CC motif) ligand 7 | −7.5 |
| Ccl8 | Chemokine (CC motif) ligand 8 | −3.5 |
| Ccl12 | Chemokine (CC motif) ligand 12 | −14.3 |
| Ccl20 | Chemokine (CC motif) ligand 20 | −2.0 |
| Ccr3 | Chemokine (CC motif) receptor 3 | −2.2 |
| Ccr5 | Chemokine (CC motif) receptor 5 | −2.1 |
| Cxcl10 | Chemokine (CXC motif) ligand 10 | 2.5 |
| Il2 | IL-2 | 4.5 |
| Il6 | IL-6 | 2.1 |
| Il8ra | IL-8Rα | 2.6 |
| Mif | Macrophage migration inhibitory factor | −2.2 |
| Tnf | TNF | 2.0 |
| Ag uptake and presentation | ||
| Cd1d2 | CD1d2 Ag | 2.4 |
| Stat2 | Signal transducer and activator of transcription 2 | 11.0 |
| Cd4 | CD4 Ag | −2.3 |
| Cd40 | CD40 Ag | 3.7 |
| Icam1 | ICAM-1 | 2.5 |
| Cell surface receptors | ||
| Cd36 | CD36 Ag | −3.8 |
| Fcgr1 | FcR, IgG, high affinity I | −3.1 |
| Fcer2a | FcR, IgE, low affinity II, α polypeptide | 3.1 |
| Lrp1 | Low-density lipoprotein receptor-related protein 1 | −4.4 |
| Signal transduction | ||
| Cdkn1a | Cyclin-dependent kinase inhibitor 1A (P21) | 2.0 |
| Csf1r | CSF 1 receptor | −2.2 |
| Fcamr | FcR, IgA, IgM, high affinity | 2.6 |
| Itgam | Integrin α M | −4.2 |
| Pdia3 | Protein disulfide isomerase-associated 3 | 5.5 |
The array was repeated three times to validate the findings.
−, Downregulation.