Figure 3.

NI rats exhibit decreased neuronal inhibition within the HP compared with controls. Rats treated with PBS or E. coli on P4 were injected as adults with SAL or LPS, and 24 h later received Fear Conditioning or Shock only (n = 8/group). Brains were collected 2 h later, and target genes were assessed. a, CD200 and its receptor (CD200R) were reduced overall in NI rats compared with controls in the fear conditioned group (*p < 0.01 for both), whereas only CD200R was significantly decreased by LPS (**p < 0.02). b, There were no neonatal group differences in CD200 or CD200R in the Shock only group; however, both genes were decreased by LPS (**p < 0.02). c, d, Fractalkine receptor (CX3CR1) but not its ligand was reduced overall in NI rats in both Fear Conditioned and Shock only groups. (*p < 0.05 for all, compared with PBS). Error bars indicate SEM.