Table 2.

Meta-analysis, top findings in whites and follow-up in the German AFNET and in African Americans

Locus				CARe Whites			AFNET				CARe African Americans
SNP nearby gene	Chromo-some position	Effect allele	EAF,† range	Beta±SE	RR, 95% CI	P value	EAF	Beta±SE	OR, 95% CI	P value	EAF, range	Beta±SE	HR, 95% CI	P value
rs2200733 PITX2	4 111929618	C	0.87–0.89	−0.33±0.04	0.72 0.66–0.78	2.5×10−16	--	--	--	--	0.78–0.81	−0.31±0.10	0.73 0.60–0.89	0.0018
rs198358 NPPA	1 11826663	C	0.22–0.24	−0.15±0.03	1.16 1.09–1.25	0.000012	0.25	−0.14±0.13	0.87 0.67–1.13	0.26	0.52–0.52	−0.05±0.09	0.95 0.80–1.13	0.56
rs2066470 MTHFR	1 11785644	A	0.08–0.10	0.18±0.05	1.20 1.09–1.31	0.00014	0.11	−0.31±0.18	0.73 0.51–1.05	0.10	0.07–0.08	0.05±0.17	1.05 0.76–1.45	0.76
rs4845625 IL6R	1 152688691	C	0.57–0.58	−0.11±0.03	0.90 0.85–0.95	0.00048	0.53	–0.07±0.03	0.71 0.57–0.89	0.003	0.69–0.70	−0.15±0.09	0.86 0.72–1.03	0.09
rs5997788 OSBP2	22 29585029	G	0.48–0.51	−0.14±0.03	0.87 0.82–0.92	3.3×10−6	0.48	−0.005±0.12	1.00 0.79–1.25	0.97	0.61–0.61	0.08±0.09	1.08 0.90–1.29	0.39
rs361557 TUBA8	22 16991223	A	0.81	0.15±0.04	1.16 1.08–1.26	0.00014	0.81	0.17±0.15	1.19 0.89–1.59	0.22	0.21–0.25	0.25±0.10	1.29 1.06–1.57	0.01
rs4586205 DRD2	11 112812339	G	0.23–0.25	0.14±0.03	1.15 1.08–1.23	4.5×10−5	0.25	−0.01±0.13	0.99 0.76–1.27	>0.99	0.64–0.65	0.10±0.09	1.10 0.92–1.33	0.29
rs998422 SLC2A10	20 44792815	A	0.57–0.59	0.11±0.03	1.11 1.05–1.18	0.0005	0.42	−0.24±0.11	0.79 0.63–0.98	0.03	0.83–0.84	−0.02±0.12	0.98 0.78–1.23	0.83

The abbreviations are as follows: AA, African Americans; EAF, Effect allele frequency; OR, odds ratio; RR, relative risk, SE, standard error; SNP, single nucleotide polymorphism.

^†Range of EAFs across cohorts. Analyses were modeled for the alleles in alphabetical order. The effect allele was the allele earlier in the alphabet.