Table 2. Allele and genotype association analysis between XFS/XFG versus all controls and XFS/XFG versus controls aged 70 years or above.
|
|
XFS/XFG (n=89) |
All controls (n=146) |
Controls aged 70 years or above (n=110) |
||||
|---|---|---|---|---|---|---|---|
| SNP | Count (proportion) | Count (proportion) | p value | OR (95% CI) | Count (proportion) | p value | OR (95% CI) |
|
rs1048661 | |||||||
| Allele | |||||||
| T |
165 (0.93) |
188 (0.64) |
5.744×10−12 |
7.02 (3.80–12.97) |
135 (0.61) |
5.423×10−13 |
7.99 (4.27–14.95) |
| G |
13 (0.07) |
104 (0.36) |
|
|
85 (0.39) |
|
|
| Genotype | |||||||
| TT |
80 (0.90) |
64 (0.44) |
2.066×10-12* |
11.39 (5.31–24.42)* |
45 (0.41) |
1.177×10-12* |
12.84 (5.85–28.21)* |
| GT |
5 (0.06) |
60 (0.41) |
|
|
45 (0.41) |
|
|
| GG |
4 (0.04) |
22 (0.15) |
|
|
20 (0.18) |
|
|
|
rs3825942 | |||||||
| Allele | |||||||
| G |
175 (0.98) |
261 (0.89) |
0.0003 |
6.93 (2.09–23.01) |
193 (0.88) |
6.950×10−5 |
8.16 (2.43–27.37) |
| A |
3 (0.02) |
31 (0.11) |
|
|
27 (0.12) |
|
|
| Genotype | |||||||
| GG |
86 (0.97) |
116 (0.80) |
0.0003* |
7.11 (2.10–24.08)* |
85 (0.77) |
9.441×10-5* |
8.43 (2.45–28.98)* |
| GA |
3 (0.03) |
27 (0.18) |
|
|
23 (0.21) |
|
|
| AA |
0 (0.00) |
3 (0.02) |
|
|
2 (0.02) |
|
|
|
rs2165241 | |||||||
| Allele | |||||||
| C |
175 (0.98) |
265 (0.91) |
0.0011 |
5.94 (1.35–11.71) |
199 (0.90) |
0.0011 |
6.16 (1.81–20.99) |
| T |
3 (0.02) |
27 (0.09) |
|
|
21 (0.10) |
|
|
| Genotype | |||||||
| CC |
87 (0.98) |
122 (0.84) |
0.0008* |
8.58 (1.97–37.16)* |
92 (0.84) |
9.910×10-4* |
8.51 (1.92–37.76)* |
| CT |
1 (0.01) |
21 (0.14) |
|
|
15 (0.14) |
|
|
| TT | 1 (0.01) | 3 (0.02) | 3 (0.03) | ||||
SNP, single nucleotide polymorphism; XFS, Exfoliation syndrome; XFG, Exfoliation glaucoma; OR, odds ratio; The asterisks (*) indicate the p values and OR ratios derived from comparison of the specific genotype with all of the others, i.e., TT versus GT+GG at rs1048661, GG versus GA+AA at rs3825942, CC versus CT+TT at rs2165241.