Table 3. Allele and genotype association analysis between controls versus XFS and controls versus XFG.
|
|
Control (n=146) |
XFS (n=28) |
XFG (n=61) |
||||
|---|---|---|---|---|---|---|---|
| SNP | Count (proportion) | Count (proportion) | p value | OR (95% CI) | Count (proportion) | p value | OR (95% CI) |
|
rs1048661 | |||||||
| Allele | |||||||
| T |
188 (0.64) |
52 (0.93) |
2.455×10−5 |
7.19 (2.53–20.44) |
113 (0.93) |
4.094×10−9 |
6.95 (3.38–14.27) |
| G |
104 (0.36) |
4 (0.07) |
|
|
9 (0.07) |
|
|
| Genotype | |||||||
| TT |
64 (0.44) |
24 (0.86) |
4.906×10-5* |
7.69 (2.54–23.28)* |
56 (0.93) |
1.840×10-10* |
14.35 (5.43–37.91)* |
| GT |
60 (0.41) |
4 (0.14) |
|
|
1 (0.02) |
|
|
| GG |
22 (0.15) |
0 (0.04) |
|
|
4 (0.07) |
|
|
|
rs3825942 | |||||||
| Allele | |||||||
| G |
261 (0.89) |
55 (0.98) |
0.036 |
6.53 (0.87–48.87) |
120 (0.98) |
0.002 |
7.13 (1.68–30.26) |
| A |
31 (0.11) |
1 (0.02) |
|
|
2 (0.02) |
|
|
| Genotype | |||||||
| GG |
116 (0.80) |
27 (0.96) |
0.032* |
6.98 (0.91–53.48)* |
59 (0.97) |
0.002* |
7.63 (1.76–33.03)* |
| GA |
27 (0.18) |
1 (0.04) |
|
|
2 (0.03) |
|
|
| AA |
3 (0.02) |
0 (0.00) |
|
|
0 (0.00) |
|
|
|
rs2165241 | |||||||
| Allele | |||||||
| C |
265 (0.91) |
56 (1.00) |
0.018 |
1.10 (1.06–1.14) |
119 (0.98) |
0.015 |
4.04 (1.20–13.58) |
| T |
27 (0.09) |
0 (0.00) |
|
|
3 (0.02) |
|
|
| Genotype | |||||||
| CC |
122 (0.84) |
28 (1.00) |
0.021* |
1.20 (1.11–1.29)* |
59 (0.96) |
0.009* |
5.80 (1.33–25.38)* |
| CT |
21 (0.14) |
0 (0.00) |
|
|
1 (0.02) |
|
|
| TT | 3 (0.02) | 0 (0.00) | 1 (0.02) | ||||
SNP, single nucleotide polymorphism; XFS, Exfoliation syndrome; XFG, Exfoliation glaucoma; OR, odds ratio. The asterisks (*) indicate the p values and OR ratios derived from comparison of the specific genotype with all of the others, i.e., TT versus GT+GG at rs1048661, GG versus GA+AA at rs3825942, CC versus CT+TT at rs2165241.