Table 4. Allele and genotype association analysis between controls versus unilateral XFS/XFG and controls versus bilateral XFS/XFG.
|
|
Control (n=146) |
Unilateral XFS/XFG (n=70) |
Bilateral XFS/XFG (n=19) |
||||
|---|---|---|---|---|---|---|---|
| SNP | Count (proportion) | Count (proportion) | p value | OR (95% CI) | Count (proportion) | p value | OR (95% CI) |
|
rs1048661 | |||||||
| Allele | |||||||
| T |
188 (0.64) |
131 (0.94) |
1.044×10−10 |
8.05 (3.93–16.49) |
34 (0.89) |
0.001 |
5.04 (1.736–14.62) |
| G |
104 (0.36) |
9 (0.06) |
|
|
4 (0.11) |
|
|
| Genotype | |||||||
| TT |
64 (0.44) |
63 (0.90) |
1.110×10-10* |
11.53 (4.95–26.86)* |
17 (0.89) |
0.0001* |
11.69 (2.59–52.62)* |
| GT |
60 (0.41) |
5 (0.07) |
|
|
0 (0.00) |
|
|
| GG |
22 (0.15) |
2 (0.03) |
|
|
2 (0.11) |
|
|
|
rs3825942 | |||||||
| Allele | |||||||
| G |
261 (0.89) |
137 (0.98) |
0.002 |
5.52 (1.62–18.06) |
38 (1.00) |
0.026 |
NA |
| A |
31 (0.11) |
3 (0.02) |
|
|
0 (0.00) |
|
|
| Genotype | |||||||
| GG |
116 (0.80) |
67 (0.96) |
0.002* |
5.54 (1.62–18.86)* |
19(1.00) |
0.027* |
NA* |
| GA |
27 (0.18) |
3 (0.04) |
|
|
0 (0.00) |
|
|
| AA |
3 (0.02) |
0 (0.00) |
|
|
0 (0.00) |
|
|
|
rs2165241 | |||||||
| Allele | |||||||
| C |
265 (0.91) |
139 (0.99) |
0.0007 |
14.16 (1.90–105.32) |
36 (0.95) |
0.520 |
1.62 (0.37–7.20) |
| T |
27 (0.09) |
1 (0.01) |
|
|
2 (0.05) |
|
|
| Genotype | |||||||
| CC |
122 (0.84) |
69 (0.99) |
0.0012* |
13.57 (1.808–102.53)* |
18 (0.95) |
0.248* |
3.19 (0.40–25.22)* |
| CT |
21 (0.14) |
1 (0.01) |
|
|
0 (0.00) |
|
|
| TT | 3 (0.02) | 0 (0.00) | 1 (0.05) | ||||
SNP, single nucleotide polymorphism; XFS, Exfoliation syndrome; XFG, Exfoliation glaucoma; OR, odds ratio; NA; non applicable. The asterisks (*) indicate the p values and OR ratios derived from comparison of the specific genotype with all of the others, i.e., TT versus GT+GG at rs1048661, GG versus GA+AA at rs3825942, CC versus CT+TT at rs2165241.