Table 5. Haplotype association analysis between LOXL1 SNPs and XFS/XFG.
|
Haplotype |
Proportion |
||||||
|---|---|---|---|---|---|---|---|
| rs1048661 | rs3825942 | rs2165241 | Case | Control | p value* | OR* (95% CI) | Adjusted OR** (95% CI) |
| T |
G |
C |
0.93 |
0.66 |
3.352×10−12 |
6.61 (3.58–12.22) |
7.87 (4.10–15.11) |
| T |
G |
T |
0.01 |
0.00 |
0.723 |
1.64 (0.10- 26.45) |
1.46 (0.09- 23.67) |
| T |
A |
C |
0.02 |
0.10 |
0.002 |
0.21 (0.07- 0.60) |
0.20 (0.07–0.59) |
| T |
A |
T |
0.01 |
0.07 |
0.002 |
0.08 (0.01- 0.61) |
0.06 (0.01–0.49) |
| G |
G |
C |
0.01 |
0.05 |
0.033 |
0.23 (0.05–1.01) |
0.19 (0.04–0.86) |
| G |
G |
T |
0.03 |
0.11 |
0.002 |
0.24 (0.09–0.64) |
0.22 (0.08–0.60) |
| G | A | T | 0 | 0.02 | 0.054 | NA | NA |
LOXL1, Lysyl oxidase-like 1; SNP, single nucleotide polymorphism; XFS, Exfoliation syndrome; XFG, Exfoliation glaucoma; OR, odds ratio; NA; non applicable. The single asterisk indicates the p values and OR ratios derived from comparison of the specific haplotype with all of the other haplotypes. The double asterisk indicates the OR values derived from comparison of each haplotype with other haplotypes, age, sex, RVO, DM, HTN, cardiovascular and cerebrovascular disease.