Table 7. Sensitivity, specificity, and positive and negative predictive values for the three LOXL1 SNPs.
SNP | SE (95% CI) | SP (95% CI) | PPV (95% CI) | NPV (95% CI) |
---|---|---|---|---|
rs1048661 | ||||
Allele (T) |
0.927 (0.889–0.965) |
0.356 (0.285–0.427) |
0.467 (0.393–0.541) |
0.889 (0.843–0.935) |
Genotype (TT) |
0.889 (0.836–0.962) |
0.562 (0.458–0.666) |
0.556 (0.452–0.660) |
0.901 (0.839–0.963) |
rs3825942 | ||||
Allele (G) |
0.983 (0.964–1.002) |
0.106 (0.061–0.151) |
0.401 (0.329–0.473) |
0.912 (0.870–0.954) |
Genotype (GG) |
0.966 (0.928–1.004) |
0.199 (0.116–0.282) |
0.424 (0.321–0.527) |
0.906 (0.845–0.967) |
rs2165241 | ||||
Allele (C) |
0.983 (0.964–1.000) |
0.093 (0.050–0.136) |
0.398 (0.326–0.470) |
0.900 (0.000–0.944) |
Genotype (CC) | 0.978 (0.947–1.000) | 0.164 (0.087–0.241) | 0.416 (0.313–0.519) | 0.923 (0.867–0.977) |
SNP, single nucleotide polymorphism; SE, sensitivity; SP, specificity; PPV, positive predictive values; NPV, negative predictive values.