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. Author manuscript; available in PMC: 2011 Nov 27.
Published in final edited form as: Pain. 2007 Apr 20;132(1-2):108–123. doi: 10.1016/j.pain.2007.03.003

Figure 2.

Figure 2

Repeated oral D-cycloserine (DCS) induced a long-term reduction in pain behavior in SNI rats. (A) Dose-response of pain behavior tested before (day 0), during a 2-wk treatment (gray background), and for 18 days after treatment. Rats were treated with saline or DCS (3, 10 or 30 mg/kg, p.o. twice-daily, n = 8 per group), and tested twice weekly. Tactile threshold and paw position rating of the SNI paw showed significant dose-dependent changes with treatment. (B) Re-exposure to DCS enhanced behavioral responses to the drug. Three of the four groups from (A) were re-exposed to DCS: The group that received saline in (A) was treated with DCS (30 mg/kg, naïve group), the group that received 3 mg/kg DCS was treated with saline (saline group), and the group that received 30 mg/kg DCS was re-exposed to the same treatment (redose group). Paw position and tactile threshold changes were larger for the redosed group than for the naïve group. (C) Uninjured paw tactile thresholds were not affected by treatment. Mobility, as measured in an open field, was not affected by the 2-wk DCS treatment (30 mg/kg). Asterisks indicate first and last statistically significant time points between the 30 mg/kg DCS and saline animals. Error bars indicate S.E.M.