TABLE 1.

Urinary 11β-PGF_2α and PGE-M in relation to 1% niacin and HPGDS transgenes^a

A. Estimated mean prostaglandin excretion (and 95% confidence intervals; in units of pg/mg of creatinine) among mice on the control diet, mice on 1% niacin, and HPGDS transgenic mice
	Controlb	1% Niacin	HPGDS transgenicc
11β-PGF2α	403 (285–571)	385 (230–646)	633 (326–1,228)
No. of urine samples	75	30	35
No. of mice	32	15	9
P-value	--	0.94	0.19
PGE-M	1,995 (1,224–3,251)	2,196 (1,364–3,532)	1,622 (542–4,854)
No. of urine samples	74	30	34
No. of mice	30	15	8
P-value	--	0.92	0.72

B. Relative prostaglandin excretion (and 95% confidence intervals), as compared to control values, in 4 mice that were assessed on both the control diet and the 1% niacin diet
	Control	1% Niacin	P-value
11β-PGF2α	1 (0.43–1.47)	1.34 (0.83–1.86)	0.07
No. of urine samples	13	13
No. of mice	4	4
PGE-M	1 (0–2.04)	2.85 (1.80–3.89)	0.02
No. of urine samples	14	12
No. of mice	4	4

^aData are plotted in Fig. 1. None of the mice represented here had Apc^Min alleles.

^bTwenty-seven of the control 11β-PGF_2α measurements (from 19 mice) were previously shown in Park et al. (14), as were 17 of the control PGE-M measurements (from 9 mice).

^cA subset of the data from HPGDS transgenic mice was published in Park et al. (14). However, the results shown here include data from 13 new urine specimens (including 3 specimens from 2 new mice) for 11β-PGF_2α and 5 new urine specimens (including 2 specimens from one new mouse) for PGE-M.