Table 2.
Liquid to solid ratios used in bioaccessibility extractions and recommended dosing information.
| Samples (IDs) | Ratio (mL:g)a | Minimum daily doseb (g) | Maximum daily doseb (g) |
|---|---|---|---|
| 4, 24, 26, 28, 35, 36 | 100:1 | 2.6 | 4.1 |
| 1, 2, 5, 8, 10, 14, 15, 16, 20, 21, 22, 25, 27, 29,30, 31, 32, 33, 34, 37, 38, 39, 40, 42 | 200:1 | 1.5 | 2.8 |
| 3, 11, 12, 13, 17, 18, 23, 41 | 400:1 | 1.0 | 1.4 |
| Powders 6, 7 | 100:1 | Standard ratioc | |
| 9 | 200:1 | Maximum dose of 6.1 g per day in 2000 mLd | |
| 19 | 400:1 | Maximum dose of 11 g per day in 2000 mLd |
a
Ratios are based on the daily gastric juice volume (2000 mL) corrected to the total extraction time (×5 h per 24 h=417 mL) to the maximum dose (g) of each medicine, except where noted.
b
Minimum and maximum doses are within the group of samples. All doses for individual samples were calculated as maximum, based on label information.
c
Dose could not be estimated so standard ratio was used.
d
Large daily masses resulted in ratios that were impractical for bioaccessibility extraction; 2000 mL used instead of 417 mL.