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miRNA regulatory circuits. A. The cardiac specific miR-208 family is encoded within the introns of myosin heavy chain (MHC) genes. miR-208 targets THARP1, which then down regulates the expression of β-MHC gene. B. Expression of miR-124 is negatively regulated by the binding of the RE1 silencing transcription (REST) factor to the promoter in non-neuronal cells. C. Examples of feed-back regulation of microRNA transcription through the repression of transcription factors.
