Table 2.

Plasma concentrations of amodiaquine and desethylamodiaquine

	Median (Range) (N) Concentration (ng/mL)
	AS+AQ	AS/AQ
Amodiaquine
Pre-dose 1	3.54 (n/a) (1)	1.96 (n/a) (1)
Post-dose 3	15.0 (3.8 – 48.9) (32)	14.1 (5.6 – 54.4) (30)
Desethylamodiaquine
Pre-dose 1	7.7 (1.0 – 108.9) (15)	9.3 (1.6 – 137.1) (15)
Post-dose 3	396.6 (86.9 – 1307.8) (32)	347.1 (143.3 – 759.3) (30)
Day-7	73.9 (40.7 – 186.9) (15)	91.5 (31.4 – 235.2) (15)
Day-14	48.8 (11.7 – 84.1) (15)	41.0 (24.1 – 99.2) (16)
Day-21	29.0 (19.2 – 47.3) (10)	17.7 (9.3 – 48.0) (18)
Day-28	17.7 (5.4 – 100.1) (18)	17.4 (5.5 – 69.9) (12)