Table 3.
Estimated pharmacokinetic parameters for desethylamodiaquine
| Parameter | Estimate (SE) | Inter-subject variation CV% |
|---|---|---|
| Ka (h-1) | 0.13 (fixed) | |
| CL/F (L kg-1 h-1) | 0.610 (0.038) | 22.7% |
| Q (L kg-1 h-1) | 0.680 (0.306) | |
| Vcentral/F (L kg-1) | 35.4 (11.5) | |
| Vperipheral/F (L kg-1) | 87.9 (17.1) | |
| T 1/2 (days) | 9.0 [7.3–11.6]1 | |
| σ | 0.457 |
1range of predicted values;
Ka – absorption rate constant; CL/F – total clearance;
Q – inter-compartmental clearance; Vcentral/F – volume of the central compartment;
Vperipheral/F – volume of the peripheral compartment; F – fraction of drug absorbed;
σ – residual additive error on the loge scale.