Table 3.

Candidate genes and validations. The score column lists log-scores of association for each locus, adjusted for testing of multiple SNPs within each locus. Scores greater than 1.3 (n=31, p<0.05) are shown. Scores 2.8 or greater indicate statistically significant associations after Bonferroni-adjustment for testing of multiple genes (highlighted and bold).

Group	Chr	Symbol	SNP Id	Score	gene
Serotonin receptors (20)	11	HTR3B	rs1176746	Ns	5-hydroxytryptamine (serotonin) receptor 3B
	10	HTR7	rs11596518	Ns	5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
Pharmacokinetic(21)	12	SLCO1B1	rs7959887	Ns	solute carrier organic anion transporter family, member 1B1
Vascular genes (7)	3	AGTR1	rs1492099	Ns	angiotensin II receptor, type 1
	7	NOS3	rs1800779	1.4	nitric oxide synthase 3 (endothelial cell)
Fuel processing and energy transfer (19,24)	11	PYGM	rs625172	2.0	phosphorylase, glycogen, muscle
	17	ACE	rs4344	Ns	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
	17	GAA	rs2304836	Ns	glucosidase, alpha; acid
	11	CPT1A	rs2924674	Ns	carnitine palmitoyltransferase 1A (liver)
	22	CPT1B	rs7238	Ns	carnitine palmitoyltransferase 1B (muscle)
	1	CPT2	rs1288335	Ns	carnitine palmitoyltransferase II
	1	AMPD1	rs2268699	Ns	adenosine monophosphate deaminase 1 (isoform M)
	4	COQ2	rs4693570	4.4	para-hydroxybenzoate-polyprenyltransferase
	9	APTX	rs10813916	Ns	aprataxin
Diseases (muscular dystrophy, rippling muscle disease) (19, 24)	X	DMD	rs5935419	Ns	dystrophin
	18	AQP4	rs151251	Ns	aquaporin 4
	19	DMPK	rs672348	2.8	dystrophia myotonica-protein kinase
	8	FAM82B	rs1542081	Ns	family with sequence similarity 82, member B
	3	CAV3	rs11916022	Ns	caveolin 3
Calcium transport (19)	12	ATP2B1	rs17381194	3.1	ATPase, Ca++ transporting, plasma membrane 1
	16	ATP2A1	rs205356	Ns	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
	17	ATP2A3	rs758641	Ns	ATPase, Ca++ transporting, ubiquitous
	19	RYR1	rs2960336	Ns	ryanodine receptor 1 (skeletal)
	1	RYR2	rs10925416	Ns	ryanodine receptor 2 (cardiac)
	3	ATP2B2	rs6442177	1.5	ATPase, Ca++ transporting, plasma membrane 2
	3	ATP2C1	rs218492	1.5	ATPase, Ca++ transporting, type 2C, member 1
	7	RYR3	rs6460575	1.7	ryanodine receptor 3
	X	ATP2B3	rs2269414	Ns	ATPase, Ca++ transporting, plasma membrane 3
	16	ATP2C2	rs247808	Ns	ATPase, Ca++ transporting, type 2C, member 2
	12	ATP2A2	rs17187412	Ns	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
	1	ATP2B4	rs3753036	1.8	ATPase, Ca++ transporting, plasma membrane 4