Skip to main content
. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Biomark Med. 2011 Aug;5(4):439–449. doi: 10.2217/bmm.11.33

Figure 1. Physiogenomic plots correlating LDLc with the four CYP450 combinatory drug metabolism indices.

Figure 1

Each plot contains three components: the distribution of the phenotype (bell curve), the index score of each individual patient (circles) and the LOESS fit of the index value as a function of phenotype (regression curve). In each of four panels the abscissa represents each patient’s LDLc. The ordinate indicates the index value for the LOESS curve. The p-value is derived from a linear analysis associating the index and clinical variable, and the n indicates the number of samples considered in the analysis. Correction for the comparisons of each index to five phenotypes in this study (LDLc, HDLc, LDLc:HDLc, triglycerides and BMI) requires multiplication of the respective p-value by a factor of five.

LDLc: Low density lipoprotein cholesterol; LOESS: Locally weighted scatter plot smooth.