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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Biomark Med. 2011 Aug;5(4):439–449. doi: 10.2217/bmm.11.33

Figure 3. Physiogenomic plots correlating LDLc:HDLc ratio with sertraline-specific CYP450 combinatory indices.

Figure 3

Each plot contains three components: the distribution of the phenotype (bell curve), the index score of each individual patient (circles) and the LOESS fit of the index value as a function of phenotype (regression curve). The p-value is derived from a linear analysis associating the index and clinical variable, and the n indicates the number of samples considered in the analysis. (A) Shows the inverse correlation between sertraline metabolic reserve and LDLc:HDLc ratio, and (B) shows the direct relationship between sertraline metabolic alteration and LDLc:HDLc ratio.

HDLc: High density lipoprotein cholesterol; LOESS: Locally weighted scatter plot smooth.