Table 2.
Antidepressant, antipsychotic and anticonvulsant therapy for the 96 patients for whom LDLc and HDLc lipid measures were available.
| Drug | CYP2C9 | CYP2C19 | CYP2D6 | History | At IOL |
|---|---|---|---|---|---|
| Antidepressant therapy | |||||
| Amitriptyline | 0.25 | 0.25 | 1 | 3 | NA |
| Bupropion | 0.25 | 0 | 0.25 | 32 | 22 |
| Citalopram | 0 | 1 | 0.25 | 10 | 31 |
| Doxepin | 0 | 0 | 1 | 1 | NA |
| Duloxetine | 0 | 0 | 1 | 13 | NA |
| Escitalopram | 0 | 1 | 0 | 21 | 0 |
| Fluoxetine | 1 | 0.25 | 1 | 21 | 15 |
| Fluvoxamine | 0 | 0 | 1 | 4 | NA |
| Mirtazapine | 0.25 | 0 | 1 | 5 | 6 |
| Nortriptyline | 0 | 0.25 | 1 | 1 | NA |
| Paroxetine | 0 | 0 | 1 | 23 | 2 |
| Phenelzine | 0 | 0 | 0 | 1 | NA |
| Selegiline | 0 | 0.25 | 0.25 | 1 | NA |
| Sertraline | 1 | 1 | 0.25 | 24 | 8 |
| Trazodone | 0 | 0.25 | 1 | 11 | 24 |
| Venlafaxine | 0.25 | 0.25 | 1 | 20 | 16 |
| Other | NA | NA | NA | 0 | 21 |
| Antipsychotic therapy | |||||
| Aripiprazole | 0 | 0 | 1 | 4 | 7 |
| Chlorpromazine | 0 | 0 | 1 | 1 | NA |
| Haloperidol | 0 | 0 | 1 | 3 | NA |
| Olanzapine | 0 | 0 | 0.25 | 6 | 4 |
| Quetiapine | 0 | 0 | 0.25 | 12 | 28 |
| Risperidone | 0 | 0 | 1 | 10 | 26 |
| Ziprasidone | 0 | 0 | 0 | 3 | 3 |
| Other | NA | NA | NA | 0 | 4 |
| Anticonvulsant therapy | |||||
| Divalproex | 0 | 0 | 0 | 4 | NA |
| Gabapentin | 0 | 0 | 0 | 3 | 15 |
| Lamotrigine | 0 | 0 | 0 | 4 | 10 |
| Oxcarbazepine | 0 | 0 | 0 | 2 | 4 |
| Topiramate | 0 | 0 | 0 | 1 | 5 |
| Valproic acid | 0.25 | 0.25 | 0 | 0 | 6 |
The three gene columns for CYP2C9, CYP2C19 and CYP2D6 represent the coefficients for each gene used to calculate the drug-specific metabolism indices. A value of 1 indicates a major metabolic pathway, a value of 0.25 a minor metabolic pathway and a value of 0 indicates that the gene is not involved in the drug’s metabolism. The ‘History’ column shows all drugs administered prior to hospitalization and the ‘At IOL’ column shows drugs administered during hospitalization at the IOL. NA values represent values that are either not applicable (in the case of the gene coefficients for ‘Other’ drugs) or values that are not available in our dataset.
IOL: Institute of Living; NA: Not applicable.