Table 3.
Linear models correlating LDLc (left) and HDLc (right) values to the CYP450 combinatory drug metabolism indices as well as CYP2C9, CYP2C19, CYP2D6 and CYP2C9 + CYP2D6 gene-specific indices.
| Linear Models | LDLc | HDLc | ||||||
|---|---|---|---|---|---|---|---|---|
| R2 | Met Res (%) | Met Alt (%) | Allele Alt (%) | Gene Alt (%) | Met Res (%) | Met Alt (%) | Allele Alt (%) | Gene Alt (%) |
| Combinatory | 3.40 | 10.00 | 7.20 | 11.00 | 1.47 | 3.57 | 3.95 | 7.07 |
|
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| CYP2C9 only | 1.60 | 1.60 | 1.10 | 2.00 | 3.83 | 3.83 | 3.57 | 4.70 |
|
| ||||||||
| CYP2C19 only | 0.90 | 0.90 | 0.90 | 1.40 | 0.22 | 0.22 | 0.22 | 0.04 |
|
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| CYP2D6 only | 1.20 | 9.00 | 5.20 | 4.00 | 0.60 | 3.04 | 2.41 | 4.40 |
|
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| p-value | Met Res | Met Alt | Allele Alt | Gene Alt | Met Res | Met Alt | Allele Alt | Gene Alt |
|
| ||||||||
| Combinatory | 0.075 | 0.002 | 0.009 | 0.001 | 0.252 | 0.073 | 0.059 | 0.011 |
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| CYP2C9 only | 0.228 | 0.228 | 0.314 | 0.082 | 0.063 | 0.063 | 0.073 | 0.039 |
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| CYP2C19 only | 0.355 | 0.355 | 0.355 | 0.257 | 0.662 | 0.662 | 0.662 | 0.856 |
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| CYP2D6 only | 0.296 | 0.003 | 0.026 | 0.051 | 0.467 | 0.099 | 0.141 | 0.045 |
The upper section shows the coefficient of determination (R2) for each model as a percentage. The lower section shows the statistical significance of the correlation (p-value). A value in bold indicates the strongest or most significant correlation.
Alt: Alteration; HDLc: High density lipoprotein cholesterol; LDLc: Low density lipoprotein cholesterol; Met: Metabolic; Res: Reserve.