Table 3. Differential Thermodynamic Profiles for Pairs of Dodecamer and Decamer Duplexes.
NaCla | ΔΔHc | ΔΔG°b,c | Δ(TΔS)c | ΔΔnNa+d | ΔΔnwd |
---|---|---|---|---|---|
Substitution of dA6 with 7-Deaza-dA in DDD (DDD-1 Minus DDD) | |||||
10 | 40.0 | 2.3 | 37.7 | 0.9 | 19.0 |
100 | 35.5 | 5.1 | 30.4 | 0.7 | 15.0 |
Substitution of dA5 with 7-Deaza-dA in DD (DD-1 Minus DD) | |||||
10 | 23.7 | 1.8 | 21.9 | 0.7 | 13.0 |
100 | 18.2 | 2.5 | 15.7 | 0.4 | 8.0 |
Salt concentration in mM.
Determined at 20 °C.
kcal/mol.
Per mol DNA.