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. Author manuscript; available in PMC: 2011 Nov 28.
Published in final edited form as: Cell Calcium. 2010 Nov 13;49(5):314–321. doi: 10.1016/j.ceca.2010.10.001

Figure 2. The domain structure of the 4 WT1 splice variants.

Figure 2

WT1 is a zinc finger transcription factor with 2 distinct sites for RNA splicing. WT1A is the shortest form of WT1, in that it lacks both inserts. WT1B and WT1D contain exon 5 (Ex5), a 17 aa insert located immediately 3’ of the activation domain. In addition, the tripeptide lysine-threonine-serine (KTS) is inserted immediately after zinc finger 3 (ZF3) in both WT1C and WT1D. Amino acids 1-180 are critical for dimerization of WT1, which is a prelude to transcriptional activation; amino acids 84-124 repress WT1 activity by blocking dimerization. Finally, there is a putative RNA Recognition Motif (RRM) near the N-terminus of WT1 thought to contribute to the RNA splicing functions of the KTS+ forms of WT1 (WT1C and WT1D).