FIG. 5.

Combination oncolytic virotherapy and adoptive T-cell therapy is effective against endogenous TAA, local disease. Naïve pmel T cells (1 × 10⁶) were adoptively transferred into C57BL/6 mice bearing subcutaneous B16ova (8 mice/group). Four to 6 hr later, tumors were injected with 5 × 10⁸ PFU of HI virus, VSV-GFP, or VSV-hgp100 every other day for total of six injections. (A) Survival with time or (B, C) growth of individual tumors are shown.