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. 2011 Apr 8;22(11):1389–1401. doi: 10.1089/hum.2011.031

FIG. 4.

FIG. 4.

Impact of pre-existing AAV8 NAb on vector biodistribution and day 7 NAb in macaques. (a) The amount of vector in liver (day 7) is negatively impacted by pre-existing AAV8 NAb. (b) Vector distribution to spleen is enhanced by pre-existing AAV8 NAb. (c) Dramatic increase in day 7 NAb titer in macaques with pre-existing AAV8 NAb. (d) Vector biodistribution in liver and spleen in individual animals 7 days after vector administration. Adult cynomolgus macaques (n = 8, solid circles), adult rhesus macaques (n = 8, open triangles), juvenile rhesus macaques (n = 5, open squares). Horizontal lines show the mean levels for each group. *p < 0.0001 by ANOVA Dunnett test, compared with the group with pre-NAb < 1:5. **p < 0.01, ***p < 0.0001 by Student t test.