. Author manuscript; available in PMC: 2012 Sep 27.

Published in final edited form as: ACS Nano. 2011 Aug 29;5(9):7235–7244. doi: 10.1021/nn202054f

Table 3.

Nitrogen content, NO release properties, and extent of amine to N-diazeniumdiolate conversion for the amine-functionalized silica nanoparticles.

Particle Size (nm)	μmol of AHAP^a per mg particle	[NO]_t^b (μmol mg⁻¹)		% Conversion^c	[NO]_m^d(ppm mg⁻¹)	tm^e (min)	td^f (h)
Particle Size (nm)	μmol of AHAP^a per mg particle	2 h	total	% Conversion^c	[NO]_m^d(ppm mg⁻¹)	tm^e (min)	td^f (h)
50	1.93	0.47 ± 0.02	1.49 ± 0.29	39	49.7 ± 16.8	0.8 ± 0.1	15.2 ± 2.1
100	2.37	0.38 ± 0.01	1.26 ± 0.17	27	43.5 ± 5.2	0.6 ± 0.1	13.0 ± 3.8
200	1.89	0.42 ± 0.01	1.01 ± 0.08	27	44.7 ± 8.0	0.7 ± 0.1	9.9 ± 1.6

Determined by CHN elemental analysis of control particles

[NO]_t, total number of moles of NO released per mg of particle as measured by the Griess assay

Based on assumption that 100% diazeniumdiolate conversion would result in 2 mol NO per 1 mol of AHAP in particle scaffold

[NO]_m, maximum concentration of NO released as measured with NOA.

tm, time required to reach [NO]_m

td, duration of NO release.