Figure 3. Inhibition of FAK with TAE226 leads to decreased cell invasion in SK-N-BE(2) neuroblastoma cells.
SK-N-BE(2) neuroblastoma cells were treated with TAE226 in various concentrations and matrigel invasion assays were performed. After 24 hours, the cells were fixed, stained, and counted. There was a significant decrease in the number of invading cells (4582 ± 183 vs. 2219 ± 113 cells, p<0.001, control vs. TAE226) seen with the lowest TAE226 treatment of 0.5 μM, which continued with increasing concentrations.