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. Author manuscript; available in PMC: 2011 Nov 28.
Published in final edited form as: Ageing Res Rev. 2007 May 5;7(1):49–62. doi: 10.1016/j.arr.2007.04.003

Fig. 1.

Fig. 1

Diagram illustrating a general mechanism by which diet, exercise, and other environmental challenges can affect mental health. It is postulated that control of cellular energy balance is a confluent point for the effects of environmental factors. Energy balance via interactions with BDNF, in conjunction with other factors, can modulate synaptic plasticity underlying cognitive processes.