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. Author manuscript; available in PMC: 2012 Sep 29.
Published in final edited form as: Neuroscience. 2011 Jun 29;192:773–780. doi: 10.1016/j.neuroscience.2011.06.032

Figure 1.

Figure 1

(A) Effects of exercise and tPA-STOP on the levels of proBDNF and mature BDNF in the rat hippocampus. Exercise increased both pro BDNF and mature BDNF (EC group). These increases were abolished by tPA-STOP (ET group). In the sedentary rats, tPA-STOP increased proBDNF and decreased mature BDNF (ST group). B. There was a positive correlation between running distance and mBDNF (r=0.90, p=0.01). This correction was disrupted after tPA-STOP administration (r=0.28, p=0.53) (C).

SC: Sedentary/Control; EC: Exercise/Control; ST: Sedentary/tPA-STOP; ET: Exercise/tPA-STOP. Results are expressed as means ± S.E.M. *p<0.05, **p<0.01, ***p<0.001; two-way ANOVA (exercise and drug) followed by Tukey’s range test, n=6/group.