Table 1.
Particle characterization of siRNA-loaded liposomes
| Group | Lipid molar ratio in formulation | Zeta potential (mV) | Mean particle size (nm) | Entrapment efficiency (%) |
|---|---|---|---|---|
| 1 mol% PEGylated liposome | 50:49:1 (DC-chol/DOPE/DSPE-PEG2000) | 32 ± 1.3‡ | 129.7 (51)§ | 97.66 ± 0.05‡ |
| 5 mol% PEGylated liposome | 50:45:5 (DC-chol/DOPE/DSPE-PEG2000) | 25.3 ± 1 | 147.2 (48.2) | 96.07 ± 0.07 |
| 1 mol% RGD-PEGylated liposome | 50:49:1 (DC-chol/DOPE/DSPE-PEG2000-RGD) | 24.9 ± 1.5 | 156.4 (37.5) | 98.83 ± 0.01 |
| 5 mol% RGD-PEGylated liposome | 50:45:5 (DC-chol/DOPE/DSPE-PEG2000-RGD) | 17.3 ± 0.6 | 230.7 (60.7) | 99.34 ± 0.03 |
‡
Notes: Data are the mean ± standard deviation for n = 3;
§
data are the mean (distribution width).