Table 3.
Associations between CYP19A1 and risk of rectal cancer
| Controls n |
Cases n |
ORa (95% CI) | Wald p value | pACT | |
|---|---|---|---|---|---|
| CYP19A1 (rs1961177) | 0.0188 | 0.2713 | |||
| CC | 715 | 583 | 1.00 | ||
| CT/TT | 244 | 171 | 0.75 (0.59–0.95) | ||
| CYP19A1 (rs2470144) | 0.001 | 0.0214 | |||
| GG/GA | 690 | 576 | 1.00 | ||
| AA | 269 | 178 | 0.66 (0.51–0.84) | ||
| CYP19A1 (rs7174997) | 0.0149 | 0.233 | |||
| GG | 660 | 492 | 1.00 | ||
| GT/TT | 299 | 262 | 1.32 (1.06–1.64) | ||
| CYP19A1 rs1961177(C>T) and CYP19A1 rs2470144(G>A) and CYP19A1 rs7174997(G>T) | |||||
| Frequency | Per copy risk (95% CI) | Global p value | |
|---|---|---|---|
| C-G-G | 0.37 | 1.17 (1.02–1.34) | 0.4652 |
| C-A-G | 0.33 | 0.86 (0.74–0.99) | |
| C-A-T | 0.19 | 1.12 (0.93–1.34) | |
| T-G-G | 0.11 | 0.83 (0.68–1.01) |
a
Adjusted for age, center, race, sex, and other genotypes