Table 4.

Interaction between CYP19A1 and NFκB1 and colon and rectal cancer

	Controls	Cases	ORa (95% CI)	Controls	Cases	OR (95% CI)	p Interaction	pACT
Colon cancer
		CYP19A1 (rs12591359)
NFκB1 (rs3821958)	GG/GA			AA
AA	572	447	1.00	114	96	1.08 (0.80–1.46)	0.0215	0.2890
AG	787	615	1.00 (0.85–1.18)	142	119	1.07 (0.81–1.41)
GG	300	213	0.91 (0.73–1.12)	40	63	2.01 (1.32–3.05)
		CYP19A1 (rs3751591)
NFκB1 (rs230510)	TT			TC/CC
AA	454	343	1.00	183	165	1.2 (0.93–1.55)	0.0040	0.0730
AT	615	545	1.19 (0.99–1.42)	310	197	0.84 (0.67–1.06)
TT	263	226	1.16 (0.92–1.45)	131	79	0.81 (0.59–1.11)
NFκB1 (rs3774964)
AA	531	450	1.00	261	169	0.76 (0.61–0.96)	0.0190	0.2647
AG	600	516	1.01	287	191	0.78 (0.63–0.98)
GG	201	148	0.86	76	81	1.26 (0.90–1.77)
Rectal cancer
		CYP19A1 (rs4646)
NFκB1 (rs3774964)	CC			CA/AA
AA/AG	395	343	1.00	434	279	0.74 (0.60–0.92)	0.0061	0.1908
GG	74	59	0.93 (0.64–1.35)	56	73	1.46 (1.00–2.13)
		CYP19A1 (rs700519)
NFκB1(rs11722146)	CC			CT/TT
GG	458	299	1.00	27	38	2.02 (1.20–3.41)	0.0026	0.0972
GA	337	294	1.32 (1.06–1.63)	49	34	0.99 (0.62–1.58)
AA	78	83	1.59 (1.13–2.24)	10	6	0.86 (0.31–2.42)
NFκB1 (rs1609798)
CC	432	286	1.00	25	37	2.09 (1.22–3.57)	0.0009	0.0398
CT	358	292	1.22 (0.99–1.52)	49	35	1.01 (0.63–1.60)
TT	81	97	1.77 (1.27–2.47)	12	6	0.72 (0.27–1.96)
NFκB1 (rs1801)
GG	362	237	1.00	21	34	2.33 (1.31–4.13)	0.0036	0.1235
GC	394	327	1.26 (1.01–1.57)	52	35	0.96 (0.60–1.52)
CC	117	112	1.44 (1.06–1.95)	13	9	0.98 (0.41–2.35)
NFκB1 (rs230510)
AA	260	250	1.00	40	26	0.63 (0.37–1.07)	0.0007	0.0328
AT	437	328	0.78 (0.63–0.98)	42	40	0.94 (0.59–1.50)
TT	176	98	0.58 (0.43–0.79)	4	12	2.98 (0.94–9.38)
NFκB1 (rs4648068)
AA	417	279	1.00	22	35	2.23 (1.28–3.91)	0.0026	0.0955
AG	364	305	1.23 (0.99–1.53)	53	36	0.94 (0.60–1.48)
GG	92	92	1.46 (1.05–2.03)	11	7	0.89 (0.34–2.35)

^aAdjusted for age, center, race, and sex