Table 2.
Association of Lp-PLA2 with kidney function decline over 5.7 years among elderly persons by baseline CKD
| Models | Lp-PLA2 antigena |
Lp-PLA2 activitya |
||||||
|---|---|---|---|---|---|---|---|---|
| per SD = 118 | quartile 2 | quartile 3 | quartile 4 | per SD = 113 | quartile 2 | quartile 3 | quartile 4 | |
| eGFRcreat ≥60 ml/min 1.73 m2 | ||||||||
| Subjects | 3,370 | 838 | 833 | 765 | 3,364 | 880 | 803 | 786 |
| Age, sex, race | −0.10 (−0.18, −0.03) | −0.26 (−0.47, −0.06) | −0.20 (−0.41, 0.001) | −0.26 (−0.47, −0.05) | −0.05 (−0.12, 0.03) | 0.05 (−0.15, 0.26) | −0.13 (−0.34, 0.08) | −0.01 (−0.23, 0.20) |
| + Risk factorsb | −0.10 (−0.17, −0.02) | −0.28 (−0.49, −0.07) | −0.22 (−0.43, −0.01) | −0.25 (−0.46, −0.03) | −0.04 (−0.12, 0.03) | 0.05 (−0.16, 0.26) | −0.14 (−0.35, 0.08) | −0.005 (−0.22, 0.21) |
| + CRP and IL−6 | −0.10 (−0.18, −0.02) | −0.31 (−0.52, −0.10) | −0.19 (−0.41, 0.02) | −0.26 (−0.48, −0.04) | −0.04 (−0.12, 0.04) | 0.09 (−0.12, 0.31) | −0.10 (−0.32, 0.12) | 0.0003 (−0.22, 0.22) |
| eGFRcreat <60 ml/min/1.73 m2 | ||||||||
| Subjects | 989 | 251 | 253 | 283 | 987 | 234 | 249 | 288 |
| Age, sex, race | −0.01 (−0.31, 0.28) | 0.07 (−0.30, 0.44) | −0.21 (−0.57, 0.16) | 0.11 (−0.25, 0.47) | −0.06 (−0.18, 0.05) | −0.12 (−0.49, 0.25) | −0.07 (−0.44, 0.29) | −0.19 (−0.55, 0.17) |
| + Risk factorsb | −0.02 (−0.32, 0.27) | 0.05 (−0.32, 0.42) | −0.23 (−0.60, 0.14) | 0.10 (−0.26, 0.47) | −0.07 (−0.19, 0.05) | −0.12 (−0.49, 0.25) | −0.07 (−0.44, 0.30) | −0.19 (−0.55, 0.17) |
| + CRP and IL−6 | −0.02 (−0.37, 0.32) | 0.07 (−0.32, 0.45) | −0.29 (−0.68, 0.10) | 0.10 (−0.28, 0.48) | −0.03 (−0.15, 0.10) | −0.11 (−0.50, 0.29) | −0.01 (−0.41, 0.38) | −0.06 (−0.45, 0.32) |
Results represent β (95% CI) ml/min/1.73 m2 per year, except where otherwise indicated. Baseline CKD defined by CKD-Epi eGFR ≥ or <60 ml/min/1.73 m2. Quartile 1 is the reference group.
a
Quartile ranges for Lp-PLA2 antigen (ng/ml): <257.31, 257.31–326.67, 326.68–404.68, >404.68; quartile ranges for Lp-PLA2 activity (nmol/min/ml): <30.41, 30.42–37.82, 37.83–46.60, >46.60.
b
Diabetes, systolic blood pressure, antihypertensive medications, LDL and HDL cholesterol, lipid-lowering medications, prevalent coronary heart disease.