Table 1.
Arterial blood analysis during hypoxia-asphyxia and recovery
| Baseline | Hypoxia 37 min | Room air 5 min | Asphyxia 5 min | After resuscitation |
|||
|---|---|---|---|---|---|---|---|
| 1 h | 2 h | 3 h | |||||
| pH | |||||||
| Vehicle | 7.48 ± 0.02 | 7.37 ± 0.12 | 7.34 ± 0.14 | 6.93 ± 0.06 | 7.41 ± 0.05 | 7.50 ± 0.03 | 7.51 ± 0.05 |
| EUK-134 | 7.45 ± 0.03 | 7.35 ± 0.10 | 7.34 ± 0.11 | 6.90 ± 0.09 | 7.39 ± 0.05 | 7.49 ± 0.03 | 7.50 ± 0.05 |
| Edaravone | 7.44 ± 0.05 | 7.35 ± 0.06 | 7.37 ± 0.08 | 6.89 ± 0.06 | 7.41 ± 0.08 | 7.49 ± 0.05 | 7.49 ± 0.03 |
| PaO2, mm Hg | |||||||
| Vehicle | 130 ± 14 | 22 ± 4 | 70 ± 12 | 11 ± 4 | 119 ± 21 | 137 ± 15 | 146 ± 24 |
| EUK-134 | 144 ± 9 | 20 ± 1 | 77 ± 14 | 9 ± 6 | 132 ± 19 | 146 ± 7 | 147 ± 16 |
| Edaravone | 130 ± 18 | 21 ± 3 | 89 ± 10 | 9 ± 3 | 119 ± 24 | 137 ± 22 | 144 ± 24 |
| PaCO2, mm Hg | |||||||
| Vehicle | 37 ± 6 | 36 ± 6 | 36 ± 5 | 79 ± 19 | 36 ± 4 | 34 ± 5 | 32 ± 5 |
| EUK-134 | 37 ± 4 | 34 ± 5 | 37 ± 2 | 93 ± 10 | 38 ± 5 | 33 ± 2 | 33 ± 4 |
| Edaravone | 39 ± 6 | 40 ± 6 | 35 ± 5 | 96 ± 16 | 38 ± 5 | 34 ± 5 | 34 ± 5 |
| Glucose, mg/dl | |||||||
| Vehicle | 109 ± 39 | 170 ± 52 | 136 ± 45 | 203 ± 71 | 128 ± 66 | 131 ± 67 | 118 ± 77 |
| EUK-134 | 113 ± 69 | 168 ± 74 | 157 ± 101 | 291 ± 126 | 128 ± 74 | 95 ± 35 | 95 ± 34 |
| Edaravone | 101 ± 58 | 185 ± 74 | 168 ± 56 | 293 ± 85 | 183 ± 52 | 111 ± 33 | 106 ± 50 |
Values are means ± SD measured at 37 min of hypoxia, 5 min of room air ventilation, 5 min of asphyxia, and 3 h of recovery in vehicle-, EUK-134- and edaravone-treated groups destined to survive 4 days. No differences were observed among groups.