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. Author manuscript; available in PMC: 2011 Nov 28.
Published in final edited form as: Eur J Immunol. 2008 Aug;38(8):2219–2228. doi: 10.1002/eji.200738113

Figure 4. Act1-deficnet mice develop SLE-like nephritis, increased RF and show decreased survival rate.

Figure 4

(A) Representative H&E staining of kidneys sections from Act1−/− mice or control littermates showing the kidney glomeruli (x100 magnification). The lower panel is a representative immunohistochemical staining of kidney glomeruli of 8 month old Act1+/+ or Act1−/− mice (n=4) using rat anti-mouse IgG. (B) Levels of rheumatoid factor (RF) in 4 to 10 months old Act1−/− (n=9) or Act1+/+ (n=5) mice measured by ELISA. Short horizontal bars represent the mean. A grey line is drawn across the graph to show the lowest value in Act1+/+ mice. The values below the grey line are considered positive (black filled dots). (C) Survival rates of Act1−/− mice. 30 pairs of Act1−/− mice and Act1+/+ mice were observed for mortality during a period of 12 months.