Table 2.
Cognitive profiles of common causes of dementia.
Cognitive domain | AD | Lewy body dementia | Behavioral variant frontotemporal dementia | Vascular dementia | Depression |
---|---|---|---|---|---|
Episodic memory | |||||
Free recall | +++ | ++ | +/- | + | + |
Recognition | +++ | - | - | - | - |
Prompting | x | ✓ | ✓ | ✓ | ✓ |
Intrusions | +++ | +++ | +++ | + | + |
Semantic memory (naming) | ++ | + | + | + | +/- |
Procedural memory | - | + | - | + | + |
Working memory | ++ | +++ | +++ | ++ | |
Insight | +++ | + | +++ | - | - |
Attention | ++ | +++ | ++ | ++ | +++ |
Executive functions | ++ typical AD +++ frontal variant |
+++ | +++ | +++ | ++ |
Visuospatial skills | ++ typical AD +++ PCA |
+++ | - | + | + |
+++ Early and severe impairment.
++ Moderate impairment.
+ Mild impairment.
+/- Impairment in some studies but not others.
- No significant impairment.
x Not helpful.
✓ Helpful.
Note: +++ Behavioral variant frontotemporal dementia patients often perform in the normal range on traditional executive functions tests measuring working memory, planning, mental flexibility, response inhibition and concept formation, although this may reflect the difficulty in capturing specific ‘frontal lobe’ functions on standard executive function measures.
AD: Alzheimer's disease; PCA: Posterior cortical atrophy.