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. 2011 Nov 4;11:108. doi: 10.1186/1472-6882-11-108

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Copyright ©2011 Liberio et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Serum concentration of cytokines. Serum concentration of cytokines in C57Bl/6 mice treated with topical oral gel containing propolis (GP) in comparison with the group treated only with the gel base (GS), or with saline (S). ELISA was used to determine the serum concentrations of IL-4 (A); IL-10 (B); IFN-γ (C) and TNF-α (D). The results represent mean ± standard deviation of 6 animals/group. (*) p < 0.05 in relation to the control and (#) p < 0.05 in relation to the other experimental group.