Table 1.

Tumor grade, size and stage in compare to immunohistochemicals markers (mEGFR, nEGFR, Cyclin D1) and EGFR FISH in CRC

		Grade			pT					Tumor stage
Parameters	Total	low	high	p-value	1	2	3	4	p-value	1	2	3	4	p-value
mEGFR				0.042					0.506					0.769
neg./week	49	47	2		2	35	12	0		22	4	23	0
moderate	64	54	10		0	39	23	2		22	9	33	0
strong	22	20	2		0	12	9	1		7	4	10	1
nEGFR				0.427					0.452					0.943
neg./week	9	9	0		0	6	3	0		4	2	3	0
moderate	49	44	5		2	25	20	2		15	11	22	1
strong	77	68	9		0	55	21	1		32	4	41	0
Cyclin D1				0.363					0.335					0.588
neg./week	8	8	0		0	7	1	0		4	1	3	0
moderate	51	46	5		2	24	22	3		14	11	25	1
strong	76	67	9		0	55	21	0		33	5	38	0
EGFR FISH				0.486					0.713					0.178
≤ 2.0 - 2.49	117	106	12		2	78	34	3		47	14	56	0
2.5 - 2.93	10	9	0		0	5	5	0		2	2	5	1
≥ 2.94	8	6	2		0	3	5	0		2	1	5	0
Total	135	121	14		2	86	44	3		51	17	66	1

CRC, colorectal carcinoma

mEGFR, membrane EGFR

nEGFR, nuclear EGFR

test - Spearman rank correlation coefficient