Table 2.
Aripiprazole (n = 149) | Blonanserin (n = 67) | Olanzapine (n = 95) | Perospirone (n = 36) | Quetiapine (n = 74) | Risperidone (n = 120) | |
---|---|---|---|---|---|---|
Discontinuation n (%) | 83 (55.7) | 53 (79.1) | 74 (77.9) | 27 (75.0) | 48 (64.9) | 92 (76.7) |
Time to discontinuation (day) by Kaplan–Meier analysis | 543 | 364 | 370 | 407 | 402 | 336 |
Treatment comparisons by Cox’s proportional hazards regression model | ||||||
Aripiprazole | ||||||
Hazard ratio (95% CI) | 0.63 (0.44–0.89) | 0.62 (0.45–0.85) | 0.68 (0.44–1.06) | 0.74 (0.51–1.05) | 0.58 (0.43–0.78) | |
P value | 0.008** | 0.003** | 0.086 | 0.092 | <0.001** | |
Blonanserin | ||||||
Hazard ratio (95% CI) | 0.98 (0.69–1.38) | 1.1 (0.70–1.76) | 1.16 (0.78–1.71) | 0.91 (0.65–1.28) | ||
P value | 0.9 | 0.69 | 0.48 | 0.59 | ||
Olanzapine | ||||||
Hazard ratio (95% CI) | 1.12 (0.71–1.74) | 1.16 (0.80–1.67) | 0.93 (0.69–1.27) | |||
P value | 0.63 | 0.43 | 0.65 | |||
Perospirone | ||||||
Hazard ratio (95% CI) | 1.06 (0.66–1.71) | 0.84 (0.55–1.29) | ||||
P value | 0.8 | 0.43 | ||||
Quetiapine | ||||||
Hazard ratio (95% CI) | 0.80 (0.56–1.13) | |||||
P value | 0.2 |
Note: P value is statistically significant.
Abbreviation: CI, confidence interval.