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. 2011 Nov 28;6(11):e27887. doi: 10.1371/journal.pone.0027887

Table 4. The top 10 pathways mediated by NESG1 in NPC.

Pathway Number of genes p-value Genes involving pathway
MAPK signaling pathway 29 1.14E-15 FGFR2;MAP3K14;MAP3K3;ZAK;MAP2K2;NTF4;PLA2G10;NTRK2;PPM1A;RPS6KA2;DUSP3;DUSP9;ZAK;CRK;MAP4K4;PTPRR;SOS1;NRAS;PRKCA;PPM1B;NF1;FGFR1;FOS;ATF2;MAP3K2;GRB2;ZAK;MAPKAPK2;RAPGEF2;MAX;ZAK;ZAK;RAP1A
Systemic lupus erythematosus 20 1.73E-13 HIST1H4A;HIST1H4B;HIST1H4C;HIST1H4D;HIST1H4E;HIST1H4F;HIST1H4H;HIST1H4I;HIST1H4J;HIST1H4K;HIST1H4L;HIST2H4B;HIST2H4A;HIST4H4;HLA-DMB;TROVE2;H3F3B;LOC644914;H3F3A;HIST1H2BC
Insulin signaling pathway 15 5.91E-09 PRKAA2;PRKAB1;MAP2K2;PIK3R5;CRK;SOS1;NRAS;PRKCI;PRKAB2;PHKB;PPP1CB;RHOQ;GRB2;PRKAA2;RHOQ;PRKAA2;TRIP10;PRKAR2B
Regulation of actin cytoskeleton 18 1.50E-08 FGFR2;BCAR1;ENAH;MAP2K2;PIK3R5;PAK6;ITGA2;CRK;ABI2;RDX;SOS1;NRAS;ITGB8;FGFR1;PIP5K3;WASF1;DIAPH3;ABI2;PPP1CB
Focal adhesion 17 3.52E-08 BCAR1;THBS1;PIK3R5;PAK6;ITGA2;CRK;CAV2;SOS1;PRKCA;ITGB8;ARHGAP5;COL4A2;COL4A1;PPP1CB;COL4A2;GRB2;COL4A4;RAP1A
Cell cycle 13 5.72E-08 CCNB2;E2F1;RBL2;ANAPC1;CHEK1;CDKN2B;RB1;ATM;LOC651610;MCM6;CDC14B;SMC1A;CCNA1
Wnt signaling pathway 14 1.54E-07 PRICKLE1;LRP5;FZD1;CSNK1E;CTNNBIP1;VANGL1;DKK1;WNT9A;DAAM1;CSNK1A1;VANGL2;PRKCA;NFAT5;WNT5A
Non-small cell lung cancer 9 1.63E-07 MAP2K2;PIK3R5;E2F1;PLCG2;SOS1;NRAS;PRKCA;RB1;GRB2
Renal cell carcinoma 10 1.75E-07 MAP2K2;PIK3R5;PAK6;ARNT2;CRK;SOS1;NRAS;EGLN1;GRB2;RAP1A
Jak-STAT signaling pathway 14 1.97E-07 IL24;EPOR;IFNE;PIK3R5;SOS1;LEPR;STAM2;IRF9;GRB2;IL20RB;JAK3;JAK1;IL4R;JAK3;IL2RG